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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | OAVG | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Roger Bailey | .1537 | 2007 | |
| 2 | Ryan Sherman | .1658 | 2011 | |
| 3 | Derek Duffy | .1755 | 2003 | |
| 4 | Marty Harris | .1780 | 2007 | |
| 5 | Nick Bradley | .1787 | 2006 | |
| 6 | Stephen Strasburg | .1789 | 2011 | |
| 7 | Ken Brandon | .1810 | 2019 | |
| 8 | Joaquin Benoit | .1824 | 2007 | |
| 9 | Craig Breslow | .1840 | 2011 | |
| 10 | Joel Zumaya | .1845 | 2010 | |
| 11 | Denny Bautista | .1850 | 2007 | |
| 12 | Ryan Bowen | .1854 | 1991 | |
| 13 | Jair Jurrjens | .1861 | 2013 | |
| 14 | Eduardo Ruíz | .1880 | 2024 | |
| 15 | Woodrow McKee | .1882 | 2017 | |
| 16 | Floyd Johnston | .1885 | 2008 | |
| 17 | Jonathan Jenkins# | .1887 | 2022 | |
| 18 | Malcolm Zegwaard | .1892 | 2012 | |
| 19 | Stanley High | .1897 | 2017 | |
| 20 | Ian Kennedy | .1907 | 2009 | |
| 21 | Paul Phelps | .1910 | 2014 | |
| 22 | Nick Baker | .1927 | 2015 | |
| 23 | Chuck Smith | .1928 | 2010 | |
| 24 | Craig Breslow | .1930 | 2010 | |
| 25 | Clarence Burch# | .1935 | 2023 | |
| 26 | Russ Ortiz | .1938 | 1998 | |
| 26 | Bob Schultz | .1938 | 2012 | |
| 28 | Steve Jarvis | .1949 | 2012 | |
| 29 | Tom Coughlans | .1961 | 2012 | |
| 29 | Jorge Sosa | .1961 | 2006 | |
| 31 | Stephen Smith | .1963 | 2009 | |
| 32 | Eduardo Ruíz | .1967 | 2020 | |
| 33 | James West | .1969 | 2010 | |
| 34 | Andre Hesketh# | .1971 | 2025 | |
| 35 | Bradley McGuire | .1975 | 2019 | |
| 36 | Steve Flannery | .1978 | 2010 | |
| 36 | Julio Teheran | .1978 | 2015 | |
| 38 | Darwin Francis | .1981 | 2010 | |
| 39 | Mike Bannon | .1986 | 2006 | |
| 40 | Ryan Harrison | .1994 | 2005 | |
| 41 | Fernando Guzmán | .1997 | 2008 | |
| 42 | Damian Moss | .2000 | 2005 | |
| 43 | Geremi Gonzalez | .2003 | 2007 | |
| 44 | Tyler Clippard | .2004 | 2009 | |
| 45 | Eric Hurley | .2006 | 2005 | |
| 46 | Jason Bere | .2011 | 1994 | |
| 47 | Matt Clement | .2012 | 2003 | |
| 47 | Donne Wall | .2012 | 1996 | |
| 47 | Wynn Cooke | .2012 | 2008 | |
| 50 | Steve Jarvis | .2016 | 2015 | |
| 51 | Luke Gregerson | .2022 | 2012 | |
| 51 | Ken Cowley# | .2022 | 2027 | |
| 53 | Frank Larkin | .2023 | 2001 | |
| 53 | José Tañón | .2023 | 2004 | |
| 55 | Juan Montoya | .2025 | 2012 | |
| 55 | Dave Coggin | .2025 | 2002 | |
| 55 | Chuck Smith | .2025 | 2012 | |
| 58 | Kazuhisa Ishii | .2028 | 2008 | |
| 59 | Steve Hayes | .2029 | 2017 | |
| 60 | Todd Coffey | .2032 | 2009 | |
| 61 | Scott Winchester | .2035 | 2003 | |
| 62 | Les Huggins | .2037 | 2014 | |
| 62 | Dave Márquez | .2037 | 2016 | |
| 62 | John Ward | .2037 | 2013 | |
| 65 | Nelson Taylor# | .2039 | 2027 | |
| 66 | Takashi Saito | .2041 | 2012 | |
| 67 | António Ortíz | .2042 | 2001 | |
| 68 | Tim McJannett | .2044 | 2021 | |
| 69 | Frank Barnett# | .2045 | 2022 | |
| 69 | Adam Eaton | .2045 | 2008 | |
| 71 | Chuck Smith | .2046 | 2009 | |
| 71 | Woody Baxter# | .2046 | 2024 | |
| 73 | Osvaldo Fernandez | .2052 | 1996 | |
| 74 | Eric Pollock | .2056 | 2005 | |
| 75 | Alejandro Sosa | .2057 | 2007 | |
| 76 | Rich Harden | .2058 | 2003 | |
| 77 | Jason Williams | .2063 | 2015 | |
| 78 | Douglas Fletcher | .2064 | 2002 | |
| 79 | Sweetbreads Mayer | .2066 | 2005 | |
| 80 | Chris Barker | .2067 | 2021 | |
| 80 | Denny Brooks | .2067 | 2024 | |
| 82 | Juan Vega | .2069 | 2015 | |
| 83 | Jesse Foppert | .2071 | 2004 | |
| 84 | Carlos Ramírez | .2072 | 2003 | |
| 85 | Willie E Adams | .2075 | 2008 | |
| 85 | David Lozano# | .2075 | 2021 | |
| 87 | Roy Picot | .2077 | 2006 | |
| 88 | Byron Guffin | .2082 | 2014 | |
| 89 | Brad Penny | .2083 | 2004 | |
| 90 | Veríssimo Hervedeiro | .2085 | 2006 | |
| 91 | Dan Wilkerson# | .2089 | 2023 | |
| 91 | Lee Rice | .2089 | 2007 | |
| 93 | Flynn Garrett | .2092 | 2011 | |
| 93 | Mike Thurman | .2092 | 2007 | |
| 93 | Russell Byers# | .2092 | 2021 | |
| 96 | Ash Gonzáles | .2093 | 2020 | |
| 96 | Jesús Pinamango | .2093 | 2008 | |
| 98 | Doug MacComas | .2094 | 2023 | |
| 99 | Ángel González# | .2096 | 2024 | |
| 100 | Jason Yoder | .2100 | 2023 |
