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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Steve Jarvis | 241 | 2012 | |
| 2 | Phil Barnes | 228 | 2013 | |
| 3 | Eric Pollock | 227 | 2005 | |
| 4 | Jesse Foppert | 225 | 2004 | |
| 5 | Malcolm Zegwaard | 224 | 2012 | |
| 6 | José Delgado# | 223 | 2023 | |
| 6 | Will Davidson | 223 | 2009 | |
| 8 | Dan Evans | 214 | 2010 | |
| 9 | Ryan Sherman | 211 | 2011 | |
| 10 | Bob Harper | 210 | 2012 | |
| 11 | Stephen Strasburg | 208 | 2011 | |
| 11 | Freddy Garcia | 208 | 2010 | |
| 13 | Stan Spencer | 206 | 1998 | |
| 13 | Roy Picot | 206 | 2006 | |
| 15 | Joba Chamberlain | 205 | 2012 | |
| 16 | Roger Bailey | 204 | 2007 | |
| 17 | Dave Ferneyhough | 202 | 2005 | |
| 18 | Veríssimo Hervedeiro | 200 | 2006 | |
| 19 | Joel Zumaya | 199 | 2010 | |
| 19 | Damon Lane | 199 | 2010 | |
| 21 | Eddie James# | 198 | 2020 | |
| 21 | John Kennedy# | 198 | 2024 | |
| 23 | Keith Compton | 197 | 2010 | |
| 23 | Takashi Saito | 197 | 2012 | |
| 23 | James West | 197 | 2010 | |
| 23 | Russ Ortiz | 197 | 1998 | |
| 27 | Bob Schultz | 196 | 2012 | |
| 28 | Mark Redman | 195 | 1999 | |
| 28 | Max Scherzer | 195 | 2009 | |
| 28 | Steve Jarvis | 195 | 2015 | |
| 31 | Kevin Robinson | 194 | 2009 | |
| 32 | Félix Zamora | 193 | 2009 | |
| 33 | Juan Vega | 192 | 2014 | |
| 34 | Nolan Arnold | 190 | 2011 | |
| 35 | Roger Salkeld | 189 | 2001 | |
| 36 | Stephen Smith | 188 | 2009 | |
| 37 | Luke Gregerson | 187 | 2012 | |
| 37 | Pedro Sánchez# | 187 | 2029 | |
| 37 | Lee Rice | 187 | 2007 | |
| 37 | David Bailey | 187 | 2019 | |
| 41 | Jason Covington | 186 | 2008 | |
| 41 | Joe Lewis# | 186 | 2030 | |
| 43 | Manfred Schenkel | 185 | 2003 | |
| 43 | Phil Barnes | 185 | 2009 | |
| 43 | Jorge Enríquez# | 185 | 2020 | |
| 46 | Kazuhisa Ishii | 184 | 2008 | |
| 46 | Roger Salkeld | 184 | 2000 | |
| 46 | Kevin Chamberlain | 184 | 2007 | |
| 46 | Edinson Volquez | 184 | 2015 | |
| 46 | Abraham Perea# | 184 | 2030 | |
| 46 | Justin Masterson | 184 | 2011 | |
| 52 | Wade Miller | 183 | 2002 | |
| 53 | David Bush | 182 | 2010 | |
| 54 | Bill Gill# | 181 | 2022 | |
| 54 | Chuck Smith | 181 | 2011 | |
| 56 | Bob Mason# | 180 | 2023 | |
| 56 | Andrew Bailey | 180 | 2010 | |
| 56 | Glendon Rusch | 180 | 1997 | |
| 56 | Ian Snell | 180 | 2006 | |
| 56 | Nate Pearson# | 180 | 2027 | |
| 61 | Byron Guffin | 179 | 2011 | |
| 61 | Steve Fletcher# | 179 | 2026 | |
| 63 | Chang-weon Kim# | 178 | 2029 | |
| 63 | Roger Larsen | 178 | 2020 | |
| 65 | Chris Capuano | 177 | 2005 | |
| 65 | Mike Bannon | 177 | 2010 | |
| 65 | Earl Collins | 177 | 2012 | |
| 65 | Freddy Castro | 177 | 2006 | |
| 65 | Stephen Smith | 177 | 2011 | |
| 65 | Pedro Castro | 177 | 2012 | |
| 65 | Ryan Bowen | 177 | 1991 | |
| 72 | Juan Luis Cruz# | 176 | 2029 | |
| 72 | Dave Hoffman | 176 | 2013 | |
| 72 | Mike Bannon | 176 | 2012 | |
| 72 | Leroy Rogers | 176 | 2007 | |
| 72 | Mike Bannon | 176 | 2005 | |
| 72 | Roosevelt Sweeting# | 176 | 2030 | |
| 78 | Eric Sears# | 175 | 2029 | |
| 78 | Yong-hun Yi# | 175 | 2027 | |
| 78 | Rick Snow# | 175 | 2025 | |
| 81 | Bob Morris# | 174 | 2022 | |
| 81 | Ricky Nolasco | 174 | 2011 | |
| 81 | Tony Ramírez | 174 | 2009 | |
| 81 | Dennis Kirby | 174 | 2020 | |
| 85 | Dennis Kirby | 173 | 2010 | |
| 85 | Yovani Gallardo | 173 | 2010 | |
| 85 | Mike King# | 173 | 2030 | |
| 85 | Kyle Lohse | 173 | 2012 | |
| 85 | Jasper Phillips | 173 | 2011 | |
| 85 | Roy Picot | 173 | 2005 | |
| 91 | Mike Bannon | 172 | 2011 | |
| 91 | Roger Salkeld | 172 | 1999 | |
| 91 | Dave Hoffman | 172 | 2019 | |
| 94 | Dan C Smith | 171 | 2002 | |
| 94 | Dave Ferneyhough | 171 | 2003 | |
| 94 | Roger Larsen | 171 | 2019 | |
| 94 | Paul Phelps | 171 | 2014 | |
| 94 | Julio Teheran | 171 | 2015 | |
| 94 | Flynn Garrett | 171 | 2012 | |
| 94 | Victor Dunlap | 171 | 2021 |
